The Mouse anti actin alpha-muscle Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, Rat, Chicken/Bird, Non-Human Primate, Porcine, Rabbit, and Zebrafish/Fish antigen. The Mouse anti actin alpha-muscle Antibody has been validated for the following applications: Electron Microscopy, ELISA, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
Among the six actin isoforms described in mammals, two are found in virtually all cells (beta- and gamma-cytoplasmic), two are detected in smooth muscle cells (alpha- and gamma-smooth muscle) and two are present in striated muscles, one predominantly in skeletal (alpha-skeletal) and one in cardiac (alpha-cardiac) muscle cells. These actin isoforms differ slightly in their N-terminus, but the sequence of each of these actins is highly conserved in higher vertebRates. Alpha- muscle actin is present in striated as well as smooth muscle cells, and in pathological tissues derived therefrom. It has for example been detected in several types of muscle derived tumors, and also been shown to appear in stress fibers of fibroblastic cells involved in contractile phenomena such as wound healing and fibrocontractive diseases